解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12031185
更新日期:2014-03-06 00:00:00
abstract::Marine organisms produce secondary metabolites that may be valuable for the development of novel drug leads as such and can also provide structural scaffolds for the design and synthesis of novel bioactive compounds. The marine alkaloids, clathrodin and oroidin, which were originally isolated from sponges of the genus...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12020940
更新日期:2014-02-14 00:00:00
abstract::Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A-C (1-3), consisting of hepta-peptides and new 3-β-hydroxy fatty acids from the fermentation broth of a marine-derived bacterium Bacillus subtil...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12020871
更新日期:2014-01-31 00:00:00
abstract::The marine habitat provides a large number of structurally-diverse bioactive compounds for drug development. Marine sponges have been studied over many years and are found to be a rich source of these bioactive chemicals. This study is focused on the evaluation of the activity of six diterpene derivatives isolated fro...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12020700
更新日期:2014-01-27 00:00:00
abstract::A new alkaloid, 2-(furan-2-yl)-6-(2S,3S,4-trihydroxybutyl)pyrazine (1), along with 12 known compounds, 2-(furan-2-yl)-5-(2S,3S,4-trihydroxybutyl)pyrazine (2), (S)-4-isobutyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyde (3), (S)-4-isopropyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyd...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12010477
更新日期:2014-01-21 00:00:00
abstract::Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12010069
更新日期:2013-12-24 00:00:00
abstract::Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving th...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md11125130
更新日期:2013-12-16 00:00:00
abstract::Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related kn...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11124788
更新日期:2013-12-02 00:00:00
abstract::A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114585
更新日期:2013-11-14 00:00:00
abstract::In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114510
更新日期:2013-11-12 00:00:00
abstract::Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114213
更新日期:2013-10-30 00:00:00
abstract::AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure. Marine organisms are sources of different molecules, some of which offer promising HIV-1 reverse transcriptase (RT) inhibitory activity, such as the diterpenes...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114127
更新日期:2013-10-29 00:00:00
abstract::Shrimp is one of the most popular seafoods worldwide, and its lipids have been studied for biological activity in both, muscle and exoskeleton. Free fatty acids, triglycerides, carotenoids, and other lipids integrate this fraction, and some of these compounds have been reported with cancer chemopreventive activities. ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md11103926
更新日期:2013-10-16 00:00:00
abstract::Marine natural products are a source of promising agents for cancer treatment. However, there is a need to improve the evaluation of their mechanism of action in tumors. Metabolomics of the response to anti-tumor agents is a tool to reveal candidate biomarkers and metabolic targets. We used two-dimensional high-resolu...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11103846
更新日期:2013-10-11 00:00:00
abstract::Accurate characterization of biomass constituents is a crucial aspect of research in the biotechnological application of natural products. Here we report an efficient, fast and reproducible method for the identification and quantitation of fatty acids and complex lipids (triacylglycerols, glycolipids, phospholipids) i...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11103742
更新日期:2013-09-30 00:00:00
abstract::Nanoparticle drug delivery (NDDS) is a novel system in which the drugs are delivered to the site of action by small particles in the nanometer range. Natural or synthetic polymers are used as vectors in NDDS, as they provide targeted, sustained release and biodegradability. Here, we used the chitosan and hepatoma cell...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11093517
更新日期:2013-09-17 00:00:00
abstract::Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md11093381
更新日期:2013-09-06 00:00:00
abstract::Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11093297
更新日期:2013-08-28 00:00:00
abstract::Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocraso...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11093186
更新日期:2013-08-26 00:00:00
abstract::Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11082882
更新日期:2013-08-13 00:00:00
abstract::Chemical interactions play a fundamental role in the ecology of marine foodwebs. Dimethyl sulfide (DMS) is a ubiquitous marine trace gas that acts as a bioactive compound by eliciting foraging behavior in a range of marine taxa including the copepod Temora longicornis. Production of DMS can rapidly increase following ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11072486
更新日期:2013-07-15 00:00:00
abstract::The purpose of this study is to elucidate both the chemical and conformational structure of an unfractionated fucoidan extracted from brown seaweed Turbinaria ornata collected at Nha-trang bay, Vietnam. Electrospray ionization mass spectrometry (ESI-MS) was used for determining the chemical structure and small angle X...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11072431
更新日期:2013-07-12 00:00:00
abstract::The total syntheses of the marine-derived lipopeptide natural product fellutamide B and deoxy-fellutamides B, C, and D are reported. These compounds were accessed through a novel solid-phase synthetic strategy using Weinreb amide-derived resin. As part of the synthesis, a new enantioselective route to (3R)-hydroxy lau...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11072382
更新日期:2013-07-08 00:00:00
abstract::In 2011, a Diarrhetic Shellfish Poisoning (DSP) outbreak occurred in British Columbia (BC), Canada that was associated with cooked mussel consumption. This is the first reported DSP outbreak in BC. Investigation of ill individuals, traceback of product and laboratory testing for toxins were used in this investigation....
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11051669
更新日期:2013-05-21 00:00:00
abstract::The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md11041370
更新日期:2013-04-23 00:00:00
abstract::Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments cultu...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11041316
更新日期:2013-04-22 00:00:00
abstract::In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D-F (1-3). Hyrt...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11041061
更新日期:2013-03-28 00:00:00
abstract::Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). It is an ocular manifestation of systemic disease, which affects up to 80% of all patients who have had diabetes for 10 years or more. The genetically diabetic db/db mouse, as a model of type-2 diabetes, shows dia...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11030960
更新日期:2013-03-21 00:00:00
abstract::Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likew...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md11030718
更新日期:2013-03-08 00:00:00
abstract::In the chemical investigation of marine unicellular bacteria, a new peptide, thalassospiramide G (1), along with thalassospiramides A and D (2-3), was discovered from a large culture of Thalassospira sp. The structure of thalassospiramide G, bearing γ-amino acids, such as 4-amino-5-hydroxy-penta-2-enoic acid (AHPEA),...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11030611
更新日期:2013-02-26 00:00:00
abstract::The herein presented complete structure of the core oligosaccharide of lipopolysaccharide (LPS) P. shigelloides Polish Collection of Microorganisms (PCM) 2231 (serotype O17) was investigated by (1)H, (13)C NMR spectroscopy, mass spectrometry, chemical analyses and serological methods. The core oligosaccharide is compo...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11020440
更新日期:2013-02-06 00:00:00
abstract::In order to search for sulfated polysaccharides in different invertebrate connective tissues and to examine their biological activities, we have isolated three types of polysaccharides from the body wall of the three sea cucumbers Holothuria edulis, Apostichopus japonicas and Holothuria nobilis. The physicochemical pr...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11020399
更新日期:2013-02-05 00:00:00
abstract::The dinoflagellate Dinophysis spp. is responsible for diarrhetic shellfish poisoning (DSP). In the bivalves exposed to the toxic bloom of the dinoflagellate, dinophysistoxin 3 (DTX3), the 7-OH acylated form of either okadaic acid (OA) or DTX1, is produced. We demonstrated in vitro acylation of OA with palmitoyl CoA in...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11020300
更新日期:2013-01-29 00:00:00
abstract::An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11010099
更新日期:2013-01-10 00:00:00
abstract::The marine opisthobranch Scaphander lignarius has been analyzed in the systematic search for novel bioactive compounds in Arctic marine organisms using bioassay guided fractionation. A number of highly cytotoxic fractions were shown to contain mainly polyunsaturated fatty acids (PUFAs). Selected PUFAs were isolated an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10122676
更新日期:2012-12-01 00:00:00
abstract::Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10112596
更新日期:2012-11-21 00:00:00
abstract::Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-4 and at the hydrox...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10112448
更新日期:2012-11-05 00:00:00
abstract::The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10102234
更新日期:2012-10-01 00:00:00
abstract:UNLABELLED:Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from ...
journal_title:Marine drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3390/md10092047
更新日期:2012-09-01 00:00:00
abstract::Pseudopterosins and pseudopteroxazole are intriguing marine natural products that possess notable antimicrobial activity with a commensurate lack of cytotoxicity. New semi-synthetic pseudopteroxazoles, pseudopteroquinoxalines and pseudopterosin congeners along with simple synthetic mimics of the terpene skeleton were ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10081711
更新日期:2012-08-01 00:00:00